認識乾癬

乾癬體質的成因

遺傳病學上得乾癬病白種人約1-2%,黃種人次之,黑種人最少。台灣人9%有家族史,父母當中有一人得乾癬,子女有10%罹患乾癬的機會;父母兩人得乾癬,子女則有40%罹患乾癬的機會。近幾年醫學基因研究報告,HLA-CW6與乾癬性關節炎確定相關比正常罹病多出3.3倍。
        “乾癬體質”是一種免疫過強、亢進、高度敏感的體質,例如:外來異物如細菌、病毒入侵體內,乾癬表皮細胞過度增生,許多發炎細胞聚集,其中CD8(+)T細胞直接驅動免疫反應,產生殺傷異物功能。正常人在排除異物後抑制免疫機體相對應將穩定,或降低終止免疫反應,以維持體內環境的相對穩定以確保生命的安全。所以穩定皮膚組織持續發炎、惡化,維持體內免疫平衡,即中醫治病原理陽秘陰平(超抗免疫雙向調節法)是治癒乾癬的重要契機。

認識乾癬

乾癬誘發因子及惡化因素

1.鏈球菌感染上呼吸道被偵測到有加重乾癬的證據。
2.乙型溶血性鏈球菌是急性雨滴狀及尋常型乾癬的誘發因子,也是加重發病的刺激因子;也能加重或誘發膿疱型乾癬的因素。
3.金黃色葡萄球菌的超抗原特性,也能直接活化T細胞,引起乾癬惡化。
4.寒冷地帶的冬天是乾癬病患好發期或加重惡化的氣侯因素。
5.長期睡眠不足、休息不夠、太累或壓力容易成免疫力下降;使乾癬症惡化。
6.外傷傷口也會形成乾癬 Koebner現象。
7.喝酒、辛辣食物、增強免疫力的食物、食品、燥熱補性之食材.藥材都能使乾癬症狀惡化。

認識乾癬

乾癬的種類

1.尋常型乾癬約佔乾癬比例的八成。皮膚上有鱗片狀,斑塊大小不一,真皮中微血管擴張,括去外皮常會出現點狀出血現象,病情常因歲月的痕跡,慢慢擴散或發炎組織不斷增生使表皮增厚造成粗糙、裂痕、指甲凹陷。
2.點滴狀乾癬大多出現在年輕人、小朋友身上;也常在鏈球菌喉部感染後發生。
3.手掌、腳掌膿疱型乾癬,即掌心及腳底反覆產生膿疱,並有擴散至掌背側及腳背側的嚴重案例,嚴重因素在於服用A酸、維生素D及擦類固醇後的後遺症。
4.另外一種是在指甲周圍產生膿疱,甚至將指甲破壞後消失。
5.乾癬性紅皮症-初是由斑塊型乾癬轉變而來,大多因不當治療,如使用高劑量類固醇或長期照光後覆發慢慢進展成全身脫屑性的紅斑。全身性的潮紅,紅皮症大多發於成年人,常出現畏寒或發熱、體毛大面積脫落,排汗功能降低或有淋巴結腫的現象。
6.乾癬性關節炎-乾癬病患者約有10%可能會出現關節炎,通常初期發生在手指和腳趾,嚴重也能產生關節腫大。

認識乾癬

乾癬英文解釋

From Wikipedia, the free encyclopedia
Jump to navigationJump to search
Psoriasis
Psoriasis on back1.jpg
Back and arms of a person with psoriasis
Pronunciation
/səˈraɪəsɪs, ps-, sɒ-, sɔː-, soʊ-/
(psora + -iasis)
SpecialtyDermatology
SymptomsRed (purple on darker skin), itchy, scaly patches of skin
ComplicationsPsoriatic arthritis
Usual onsetAdults
DurationLong term
CausesGenetic disease triggered by environmental factors
Diagnostic methodBased on symptoms
TreatmentSteroid creams, vitamin D3 cream, ultraviolet light, immune system suppressing medications such as methotrexate
Frequency79.7 million / 2–4%
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. These skin patches are typically red, dry, itchy, and scaly. On people with darker skin the patches may be purple in color. Psoriasis varies in severity from small, localized patches to complete body coverage. Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.


There are five main types of psoriasis: plaque, guttate, inverse, pustular, and erythrodermic. Plaque psoriasis, also known as psoriasis vulgaris, makes up about 90 percent of cases. It typically presents as red patches with white scales on top. Areas of the body most commonly affected are the back of the forearms, shins, navel area, and scalp. Guttate psoriasis has drop-shaped lesions. Pustular psoriasis presents as small non-infectious pus-filled blisters. Inverse psoriasis forms red patches in skin folds. Erythrodermic psoriasis occurs when the rash becomes very widespread, and can develop from any of the other types. Fingernails and toenails are affected in most people with psoriasis at some point in time. This may include pits in the nails or changes in nail color.


Psoriasis is generally thought to be a genetic disease that is triggered by environmental factors. If one twin has psoriasis, the other twin is three times more likely to be affected if the twins are identical than if they are non-identical. This suggests that genetic factors predispose to psoriasis. Symptoms often worsen during winter and with certain medications, such as beta blockers or NSAIDs. Infections and psychological stress can also play a role. Psoriasis is not contagious. The underlying mechanism involves the immune system reacting to skin cells. Diagnosis is typically based on the signs and symptoms.


There is no cure for psoriasis; however, various treatments can help control the symptoms. These treatments include steroid creams, vitamin D3 cream, ultraviolet light and immune system suppressing medications, such as methotrexate. About 75 percent of skin involvement improves with creams alone. The disease affects two to four percent of the population. Men and women are affected with equal frequency. The disease may begin at any age, but typically starts in adulthood. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, Crohn disease, and depression. Psoriatic arthritis affects up to 30 percent of individuals with psoriasis.

認識乾癬

乾癬成因英文解釋

Around one-third of people with psoriasis report a family history of the disease, and researchers have identified genetic loci associated with the condition. Identical twin studies suggest a 70% chance of a twin developing psoriasis if the other twin has the disorder. The risk is around 20% for nonidentical twins. These findings suggest both a genetic susceptibility and an environmental response in developing psoriasis.
Psoriasis has a strong hereditary component, and many genes are associated with it, but it is unclear how those genes work together. Most of the identified genes relate to the immune system, particularly the major histocompatibility complex (MHC) and T cells. Genetic studies are valuable due to their ability to identify molecular mechanisms and pathways for further study and potential medication targets.
Classic genome-wide linkage analysis has identified nine loci on different chromosomes associated with psoriasis. They are called psoriasis susceptibility 1 through 9 (PSORS1 through PSORS9). Within those loci are genes on pathways that lead to inflammation. Certain variations (mutations) of those genes are commonly found in psoriasis. Genome-wide association scans have identified other genes that are altered to characteristic variants in psoriasis. Some of these genes express inflammatory signal proteins, which affect cells in the immune system that are also involved in psoriasis. Some of these genes are also involved in other autoimmune diseases.
The major determinant is PSORS1, which probably accounts for 35%–50% of psoriasis heritability.[31] It controls genes that affect the immune system or encode skin proteins that are overabundant with psoriasis. PSORS1 is located on chromosome 6 in the major histocompatibility complex (MHC), which controls important immune functions. Three genes in the PSORS1 locus have a strong association with psoriasis vulgaris: HLA-C variant HLA-Cw6,[32] which encodes a MHC class I protein; CCHCR1, variant WWC, which encodes a coiled coil protein that is overexpressed in psoriatic epidermis; and CDSN, variant allele 5, which encodes corneodesmosin, a protein which is expressed in the granular and cornified layers of the epidermis and upregulated in psoriasis.
Two major immune system genes under investigation are interleukin-12 subunit beta (IL12B) on chromosome 5q, which expresses interleukin-12B; and IL23R on chromosome 1p, which expresses the interleukin-23 receptor, and is involved in T cell differentiation. Interleukin-23 receptor and IL12B have both been strongly linked with psoriasis.[32] T cells are involved in the inflammatory process that leads to psoriasis. These genes are on the pathway that upregulate tumor necrosis factor-α and nuclear factor κB, two genes involved in inflammation. Recently,[when?] the first gene directly linked to psoriasis has been identified. A rare mutation in the gene encoding for the CARD14 protein plus an environmental trigger was enough to cause plaque psoriasis (the most common form of psoriasis).

醫師介紹

羅永欽 中醫師乾癬權威

羅永欽 中醫師


羅永欽中醫師本人專治乾癬同時也擔任長生慈善會長達七年之久。
本人從68年中醫師特考及格後,就繼承家父只看痔瘡一科 


媒體報導:
1050422-1.jpg
引用來源:中醫內外用藥通穴道 痔瘡女找回暢快人生

Location

Contact Me/聯絡

GET IN TOUCH/請填寫資料

Verification Code: